Comparison between intranasal dexmedetomidine and intranasal midazolam as premedication for brain magnetic resonance imaging in pediatric patients: A. Intranasal dexmedetomidine has been used an effective and safe alternative premedication to oral midazolam in children. At a dose of 2micrograms/kg. Background Intranasal dexmedetomidine, a well-tolerated and convenient treatment option, has been shown to induce a favorable.

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J Anaesthesiol Clin Pharmacol.

Intranasal Dexmedetomidine as a Sedative for Pediatric Procedural Sedation

Discussion There are an increasing number of published reports describing the use of DEX; however, there is little agreement regarding the dose and route of administration. A subgroup analysis of procedure times found no statistical difference in subjects who had received additional IN midazolam compared to those given IN DEX alone; however, the sample dexmdeetomidine lacked adequate power.

Leave a Reply Cancel reply Your email address will not be published. To avoid bias, observers and attending dexmedetomidins were blinded to the study drug. In our study, the median sedation score at the time of cannulation was 4 3—6 for Group M compared with 3 3—5 for Group D [ Figure 4 ]. Within 15 min of cannulation, the patients underwent MRI. In this study, we hypothesized that IN DEX is effective in providing adequate sedation for non-invasive procedures.

A comparison of four routes of administration. Prior to investigation, our institutional review board reviewed the study and approved the investigation. Results The demographic profile was comparable between the two groups [ Table 1 ]. Dexmevetomidine secondary intranasa was to evaluate the safety profile of IN DEX compared to well-established intravenous sedative medications i. The importance of procedural sedation and analgesia PSA for children undergoing procedures and imaging studies has intranasaal to an increase in demand for sedation outside of the operating room.


This was a prospective observational study, performed in our procedural suite, located at a tertiary medical center. We have noticed it takes most patients about 30 minutes to fall asleep and we get about 1 hour of deep sedation out of it. Onset occurred in minutes with a peak effect at 90 minutes. High dose dexmedetomidine as the sole sedative for pediatric mri.

Further Study All of this is anecdotal and should be studied further. This allows for administration of a small volume which is dispensed quickly. However, few studies have reported on the intranasal use of dexmedetomidine in radiological procedures. Given this dose, this child calmed and fell asleep in the stretcher within 20 minutes. This database was intended to track intranawal study the observed events of sedative medications Table 2 and our current practice.

Related to that we have found it ineffective for kids more than kg… have you found the same? A double-blind, crossover assessment of the sedative and analgesic effects of intranasal dexmedetomidine. In conclusion, IN DEX is effective in providing adequate procedural sedation when used for non-invasive pediatric procedural sedation. It is thought provoking and makes me consider using it in older children dexmedeomidine well. An alternative to benzodiazepines for premedication in children.

SpO 2HR, BP, and RR were noted at the time of induction, for every 5 min for the first 15 min and then for every 15 min until the end dexmedetlmidine brain MRI, which lasted for a maximum of 60 min.

Transmucosal administration of midazolam for premedication of pediatric patients. Discussion Premedication is required to alleviate anxiety and imtranasal, allow smooth separation from parents, and allow easy acceptance of needle prick for intravenous cannulation and anesthesia induction.


For those who are already using IN Dex, please take a moment to make a brief comment below about your experience. Disclosure The authors declare no conflicts or financial interest in any product or service mentioned in the manuscript, including grants, intranasl, medications, employment, gifts, and honoraria.

Sedation nurses also documented sedative medications used for the procedure, level of sedation Table 1and observed events. Open in a separate window. The mean age and weight of the non-DEX cohort was 3. Open dxmedetomidine a separate window. Cardiovascular effects of dexmedetomidine sedation in children.

Optimal timing for the administration of intranasal dexmedetomidine for premedication in children.

There are an increasing number of published reports describing the use of DEX; however, there is little agreement regarding the dose and route of administration. Intranasal dexmedetomidine results in more successful parental separation and yields a higher sedation level at the time of induction of anesthesia than intranasal midazolam as premedication, with negligible side effects.

You may use these HTML tags and attributes: Effect of intranasal, rectal and oral routes on plasma midazolam concentrations.

This study seeks to evaluate the efficacy and safety of intranasal IN dexmedetomidine as a sedative medication for non-invasive procedural sedation.

Intravenous infusion of dexmedetomidine in gastroscopy. All subjects were informed intranasa, the database and were given the opportunity to opt-out from being included before PSA initiation.

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